A practical reference on intranasal route: what it is, how it behaves, what the literature reports, and where the honest uncertainties sit.
This page was last updated on 2026-04-04 and is reviewed periodically as new material appears.
Published research covers ischemic stroke, traumatic brain injury, cognitive impairment, optic nerve conditions and attention-related measures. Much of the human evidence comes from small trials conducted in one country, which limits how far the results generalize. Animal models supply the larger share of the data, and effects seen in rodents do not transfer automatically to people. Reviews have noted that methodological reporting is often incomplete, making it difficult to pool results or compare treatment schedules across studies.
Pharmacokinetic accounts emphasize rapid breakdown. After intravenous dosing the intact peptide disappears from blood within minutes, and nasal delivery produces low but measurable concentrations. Metabolites rather than the parent molecule may account for part of the observed activity, although the relative contribution is unresolved. Dosing in the literature varies widely and no optimal schedule has been agreed. These gaps are regularly cited as a reason the findings have not produced broad clinical adoption beyond the original research setting.
Clinical evidence consists largely of small trials with modest sample sizes, often without independent replication. Reported endpoints include cognitive scores, recovery after stroke, and visual function, but study designs vary widely and few trials meet contemporary reporting standards. Systematic reviewers have noted a high risk of bias in several of these reports. No large multicenter trial conducted outside Russia has been published. The compound is therefore best described as investigational in most jurisdictions, with its clinical role still unresolved.
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Its chain combines the first seven residues of corticotropin with a C-terminal proline-glycine-proline extension, a modification intended to slow enzymatic breakdown. The free peptide has a molecular mass near 813.9 daltons. It belongs to the class of ACTH-derived fragments studied for central nervous system activity rather than for adrenal steroid stimulation. This structural relationship to a natural hormone fragment is the usual starting point for describing the compound in the literature.
| Property | Value | Notes |
|---|---|---|
| Primary research models | Rodent studies | Largest share of published data |
| Reported markers | BDNF and NGF expression | Measured mainly in animal tissue |
| Common administration | Intranasal | Matches the registered formulation |
| Blood residence time | Minutes | Rapid enzymatic degradation |
| Evidence quality | Small trials, limited replication | Noted repeatedly in reviews |
Identity and purity are established with standard peptide methods. Reversed-phase HPLC with ultraviolet detection near 214 nm resolves the parent peak from deletion and truncation byproducts, and reports typically quote a main-peak percentage. Mass spectrometry by electrospray or MALDI-TOF confirms the expected molecular mass, while amino acid analysis or peptide mapping can verify composition when the sequence itself is in question. A certificate of analysis that pairs a chromatogram with a mass spectrum is more informative than a purity figure alone. Counter-ion content and residual solvents are separate specifications and are frequently omitted.
Semax is normally supplied as a lyophilized powder, and that form is the most stable. Suppliers commonly recommend storage at -20 °C in a desiccated container protected from light, with short-term handling at room temperature limited to weighing and transfer. Powder that has absorbed moisture degrades faster, so vials should be warmed to ambient temperature before opening to prevent condensation on the contents. Hygroscopic behavior is typical of short hydrophilic peptides, and humidity control matters more than temperature alone for long-term retention.
Regulatory status differs sharply between jurisdictions. In Russia the peptide is registered as a prescription nasal preparation, while agencies such as the United States Food and Drug Administration have not approved it for any indication. Products sold elsewhere are typically labeled for laboratory research only, and such labels shift responsibility for safe handling to the purchaser. Because the same name covers pharmaceutical-grade nasal drops and bulk research powder, identity and purity documentation becomes the main practical concern when comparing sources.
Semax is a synthetic seven-amino-acid peptide whose sequence extends the ACTH(4-10) fragment with a C-terminal proline-glycine-proline tripeptide. The commonly cited sequence is Met-Glu-His-Phe-Pro-Gly-Pro, giving a molecular formula near C37H51N9O10S and a molecular weight close to 813.9 g/mol. It belongs to the broader class of synthetic ACTH fragments studied for central nervous system effects rather than for adrenal steroid stimulation. In practice the material appears as a lyophilized white powder for laboratory work or as a dilute saline solution in clinical settings.
Development is attributed to researchers at the Institute of Molecular Genetics in Moscow during the early 1980s, building on earlier Soviet work with ACTH fragments. Russian regulatory approval followed for intranasal use, and the compound has remained commercially available there for decades. Most published human data originate from Russian and, later, some Eastern European clinical reports, which are not always accessible in English translation. Outside that region the material is generally handled as a research chemical rather than a licensed medicine.
常规纯度与身份确认依赖反相高效液相色谱，并辅以质谱测定分子量。氨基酸组成分析可用于验证序列构成，肽图分析则能进一步定位修饰或降解产物。杂质谱通常关注缺失序列肽、截短片段和氧化产物。不同方法的检出限并不相同，因此各实验室报告的纯度数值不宜直接横向比较。
多数实验室与市售的 Semax 以冻干粉形式提供。冻干粉通常建议保存在 -20 °C 或更低温度下，同时避免光照与反复升温。短期运输有时采用冷藏条件，但长期保存仍以冷冻为主。分包操作应尽量减少开盖次数，以降低吸湿和微生物污染的风险。开封后若未一次用完，建议在干燥环境中密封并尽快放回低温储存。
溶液状态的稳定性明显低于冻干粉。肽类在水溶液中可能经历水解、氧化与聚集，其中甲硫氨酸和天冬酰胺等残基常是敏感位点。Semax 含有甲硫氨酸，因此氧化风险相对突出。工作液一般主张现配现用，或冷藏并在数日内用尽。缓冲液种类、pH 和离子强度都会影响降解速率，而关于最佳条件的公开数据并不统一。
=== Differences between PAM and BLOSUM === PAM matrices are based on an explicit evolutionary model (i.e. replacements are counted on the branches of a phylogenetic tree: maximum parismony), whereas the BLOSUM matrices are based on an implicit model of evolution. The PAM matrices are based on mutations observed throughout a global alignment, this includes both highly conserved and highly mutable regions. The BLOSUM matrices are based only on highly conserved regions in series of alignments forbidden to contain gaps. The method used to count the replacements is different: unlike the PAM matrix, the BLOSUM procedure uses groups of sequences within which not all mutations are counted the same. Higher numbers in the PAM matrix naming scheme denote larger evolutionary distance, while larger numbers in the BLOSUM matrix naming scheme denote higher sequence similarity and therefore smaller evolutionary distance. Example: PAM150 is used for more distant sequences than PAM100; BLOSUM62 is used for closer sequences than BLOSUM50.
Gunston, Bill. An Illustrated Guide to Allied Fighters of World War II. London: Salamander Books Ltd, 1981. ISBN 0-668-05228-7. Gunston, Bill. Aerei della seconda guerra mondiale (in Italian). Milan: Peruzzo editore, 1984. No ISBN. Gunston, Bill and Mike Spick. Modern Air Combat. Crescent Books, 1983, ISBN 91-972803-8-0. Gunston, Bill. North American P-51 Mustang. New York: Gallery Books, 1990. ISBN 0-8317-1402-6. Gunston, Bill and Robert F. Dorr. "North American P-51 Mustang: The Fighter That Won the War." Wings of Fame, Volume 1. London: Aerospace, 1995, pp. 56–115. ISBN 1-874023-74-3. Hagedorn, Dan. Central American and Caribbean Air Forces. Tonbridge, Kent, UK: Air-Britain (Historians), 1993. ISBN 0-85130-210-6. Hagedorn, Dan. Latin American Air Wars & Aircraft. Crowborough, UK: Hikoki, 2006. ISBN 1-902109-44-9. Hammond, Grant. The Mind of War: John Boyd and American Security, Smithsonian Institution Press, 2001, ISBN 1-56098-941-6. Hastings, Max. Bomber Command. Minneapolis, Minnesota: Zenith Press, 1979. ISBN 978-0-76034-520-7. Hatch, Gardner N.; Winter, Frank H. (1993). P-51 Mustang. Paducah, KY: Turner Publishing Company. ISBN 978-1-56311-080-1. Hess, William N. Fighting Mustang: The Chronicle of the P-51. New York: Doubleday and Company, 1970. ISBN 0-912173-04-1. "History, Boeing: P-51 Mustang". Boeing. Retrieved: 24 June 2014. Jackson, Robert. Aircraft of World War II: Development, Weaponry, Specifications. Edison, New Jersey: Chartwell Books, 2003. ISBN 0-7858-1696-8. Jackson, Robert. Mustang: The Operational Record.
=== Temperature === Two issues are involved when considering the temperature of a ligation reaction. First, the optimum temperature for DNA ligase activity which is 37°C, and second, the melting temperature (Tm) of the DNA ends to be ligated. The melting temperature is dependent on length and base composition of the DNA overhang—the greater the number of G and C, the higher the Tm since there are three hydrogen bonds formed between G-C base pair compared to two for A-T base pair—with some contribution from the stacking of the bases between fragments. For the ligation reaction to proceed efficiently, the ends should be stably annealed, and in ligation experiments, the Tm of the DNA ends is generally much lower than 37°C. The optimal temperature for ligating cohesive ends is therefore a compromise between the best temperature for DNA ligase activity and the Tm where the ends can associate. However, different restriction enzymes generates different ends, and the base composition of the ends produced by these enzymes may also differ, the melting temperature and therefore the optimal temperature can vary widely depending on the restriction enzymes used, and the optimum temperature for ligation may be between 4-15°C depending on the ends. Ligations also often involve ligating ends generated from different restriction enzymes in the same reaction mixture, therefore it may not be practical to select optimal temperature for a particular ligation reaction and most protocols simply choose 12-16°C, room temperature, or 4°C.
The observation of such magnetic resonance frequencies of the nuclei present in a molecule makes it possible to determine essential chemical and structural information about the molecule. The improvements of the NMR method benefited from the development of electromagnetic technology and advanced electronics and their introduction into civilian use. Originally as a research tool it was limited primarily to dynamic nuclear polarization, by the work of Anatole Abragam and Albert Overhauser, and to condensed matter physics, where it produced one of the first demonstrations of the validity of the BCS theory of superconductivity by the observation by Charles Slichter of the Hebel-Slichter effect. It soon showed its potential in organic chemistry, where NMR has become indispensable, and by the 1990s improvement in the sensitivity and resolution of NMR spectroscopy resulted in its broad use in analytical chemistry, biochemistry and materials science. In the 2020s zero- to ultralow-field nuclear magnetic resonance (ZULF NMR), a form of spectroscopy that provides abundant analytical results without the need for large magnetic fields, was developed. It is combined with a special technique that makes it possible to hyperpolarize atomic nuclei.
According to the lipid hypothesis, elevated levels of cholesterol in the blood lead to atherosclerosis, which may increase the risk of heart attack, stroke, and peripheral artery disease. Since higher blood LDL – especially higher LDL concentrations and smaller LDL particle size – contributes to this process more than the cholesterol content of the HDL particles, LDL particles are often termed "bad cholesterol". High concentrations of functional HDL, which can remove cholesterol from cells and atheromas, offer protection and are commonly referred to as "good cholesterol". These balances are mostly genetically determined but can be changed by body composition, medications, diet, and other factors. A 2007 study demonstrated that blood total cholesterol levels have an exponential effect on cardiovascular and total mortality, with the association more pronounced in younger subjects. Because cardiovascular disease is relatively rare in the younger population, the impact of high cholesterol on health is larger in older people. Elevated levels of the lipoprotein fractions, LDL, IDL and VLDL, rather than the total cholesterol level, correlate with the extent and progress of atherosclerosis. Conversely, the total cholesterol can be within normal limits, yet be made up primarily of small LDL and small HDL particles, under which conditions atheroma growth rates are high.
Sources: en.wikipedia.org
In September 2025, facing threats from Trump to deploy the National Guard in Baltimore, Moore and Baltimore mayor Brandon Scott announced plans to increase partnership between the Baltimore Police Department, Maryland State Police, and Maryland Transportation Authority Police in high-risk areas of the city. In October 2025, Moore signed onto an amicus brief supporting a legal challenge against Trump's deployment of the National Guard for civil law enforcement in various U.S. cities.
UPMC Mercy is a 495-bed teaching and Level 1 trauma hospital located in the Bluff neighborhood adjacent to downtown and less than two miles (3 km) from UPMC Presbyterian in Oakland. Mercy was the first chartered hospital in the city of Pittsburgh and was the first hospital in the world to have been established by the Sisters of Mercy. Mercy has retained its affiliation with the Catholic Church following its merger with UPMC in January 2008.
The introduction or modification of a protecting group occasionally influences the reactivity of the whole molecule. For example, diagrammed below is an excerpt of the synthesis of an analogue of Mitomycin C by Danishefsky.
=== Other uses === A 2003 meta-analysis of existing research showed naloxone to improve blood flow in patients with shock, including septic, cardiogenic, hemorrhagic, or spinal shock, but could not determine if this reduced patient deaths. Oral naloxone has been used for opioid-induced constipation (OIC). A 2018 meta-analysis cites 5 studies that tests it for this purpose. It found that medical treatment for OIC can be more efficacious than placebo, but did not look into the effect of individual treatments such as naloxone. As a result, no conclusion can be drawn from the study on naloxone's effectiveness for OIC. Naloxone and other opioid antagonists have been examined as possible treatments for dissociative disorders. This use predicates on the theory that dissociative disorders cause disregulation in the body's natural opioid pathways. A 2023 meta-analytic study found some evidence of opioid antagonists being effective against dissociative disorders, but possible publication bias and differences in testing criteria encourages additional research.
The official language of Brazil is Portuguese (Article 13 of the Constitution of the Federal Republic of Brazil), which almost all of the population speaks and is virtually the only language used in newspapers, radio, television, and for business and administrative purposes. Brazil is the only Portuguese-speaking nation in the Americas, making the language an important part of Brazilian national identity and giving it a national culture distinct from those of its Spanish-speaking neighbors. Brazilian Portuguese has had its own development, mostly similar to 16th-century Central and Southern dialects of European Portuguese (despite a very substantial number of Portuguese colonial settlers, and more recent immigrants, coming from Northern regions, and in minor degree Portuguese Macaronesia), with a few influences from the Amerindian and African languages, especially West African and Bantu restricted to the vocabulary only. As a result, the language is somewhat different, mostly in phonology, from the language of Portugal and other Portuguese-speaking countries (the dialects of the other countries, partly because of the more recent end of Portuguese colonialism in these regions, have a closer connection to contemporary European Portuguese). These differences are comparable to those between American and British English.
Sources: en.wikipedia.org
Grades from four quarters of 7th grade and the first quarter of 8th grade (or four quarters of 8th grade and first quarter of 9th grade) in math, science, English, and social studies A standardized reading comprehension test A standardized numerical test All of these are factored into a final score. The number of students admitted into the S/T program vary from each school, but as an example, 225-250 students with the top scores are admitted to Roosevelt's Science and Technology Program. The next 60 students are placed on a waiting list. All interested 8th and 9th grade students who are residents of Prince George's County are eligible to apply for admission to the Science and Technology Center.
Hardee's Restaurants LLC is an American fast-food restaurant chain operated by CKE Restaurants Holdings, Inc. ("CKE") with locations primarily in the Southern and Midwestern United States. The company has evolved through several corporate ownerships since its establishment in 1960 in North Carolina. In April 1997, CKE Restaurants Holdings, Inc., the parent company of Carl's Jr., paid $327 million to Montreal-based Imasco Limited for Hardee's. The merger created a chain of 3,828 restaurants – 3,152 Hardee's outlets in 40 states and 10 foreign countries and 676 Carl's Jr. outlets, primarily in California. In June 2018, former CKE CEO Jason Marker announced that Carl's Jr. and Hardee's would become separate brands, claiming that CKE's racy advertising and marketing campaigns were incompatible with a family-oriented chain like Hardee's. In April 2019, Ned Lyerly, a 30-year veteran of the company and formerly president of CKE's International division, was named CEO, replacing Jason Marker. Known originally as Hardee’s Restaurant Company and later as Hardee's Food Systems, the company constructed its headquarters in 1960 at 1405–1625 N Church Street in Rocky Mount, including six buildings with 216,906 square feet, including a six story office building and five single story office and warehouse. The complex was vacated after its acquisition by CKE, with the last executives leaving in 2015.
== Feeding == The primary diet of the Wagler's pit viper consists of rodents, birds, and lizards. The pits, one on each side of the head between the eye and the nostril, are capable of detecting temperature difference of as little as 0.003 of a degree Celsius (0.0054 of a degree Fahrenheit).
The neurohypophysial hormones form a family of structurally and functionally related peptide hormones. Their representatives in humans are oxytocin and vasopressin. They are named after the location of their release into the blood, the neurohypophysis (another name for the posterior pituitary). Most of the circulating oxytocin and vasopressin hormones are synthesized in magnocellular neurosecretory cells of the supraoptic nucleus and paraventricular nucleus of the hypothalamus. They are then transported in neurosecretory granules along axons within the hypothalamo-neurohypophysial tract by axoplasmic flow to axon terminals forming the pars nervosa of the posterior pituitary. There, they are stored in Herring bodies and can be released into the circulation on the basis of hormonal and synaptic signals with assistance from pituicytes. Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels. Due to the similarity of the two hormones, there is cross-reaction: oxytocin has a slight antidiuretic function, and high levels of AVP can cause uterine contractions. In common with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms.
Fever and Taking Your Child's Temperature US National Institute of Health factsheet Drugs most commonly associated with the adverse event Pyrexia (Fever) as reported the FDA Archived 9 March 2012 at the Wayback Machine Fever at MedlinePlus Why are We So Afraid of Fevers? at The New York Times
Sources: en.wikipedia.org
The main proposal is modulation of neurotrophic factors such as brain-derived neurotrophic factor, supported largely by animal experiments. Receptor-level targets have not been firmly established. Most reviews describe the mechanism as only partially characterized.
The compound is registered as a medicine in Russia, so clinical work has concentrated there. Trials elsewhere are few and generally small. This geographic concentration is a recognized limitation in evidence reviews.
Some fraction may reach the central nervous system through olfactory pathways, and this is often cited as the rationale for the nasal route. The size of that fraction in humans is not well quantified. Blood concentrations after nasal dosing are low, which complicates measurement.
Semax is a synthetic seven-amino-acid peptide derived from a fragment of corticotropin. It is used in Russia as a nasal preparation, while elsewhere it is studied as a research compound. It is not approved as a medicine in most countries.